Dr. Arthur Yin Fan, BIOGRAPHICAL SKETCH 2015

OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015)

BIOGRAPHICAL SKETCH

Provide the following information for the Senior/key personnel and other significant contributors.

Follow this format for each person. DO NOT EXCEED FIVE PAGES.

NAME: Fan, Arthur Yin

eRA COMMONS USER NAME (agency login):

POSITION TITLE: Independent researcher in Chinese Medicine, Licensed Acupuncturist

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)

INSTITUTION AND LOCATION	DEGREE (if applicable)	Completion Date MM/YYYY	FIELD OF STUDY
Nanjing University of Chinese Medicine, Nanjing, Jiangsu	MD	06/1986	Chinese Medicine
Nanjing University of Chinese Medicine, Nanjing, Jiangsu	PHD	06/1998	Chinese Internal Medicine, Brain diseases
Nanjing University of Chinese Medicine, Nanjing Municipal Hospital of Chinese Medicine, Nanjing, Jiangsu	Resident	07/1989	Integrative medicine
Nanjing University of Medical Science Brain Hospital, Nanjing, Jiangsu	Other training	09/1990	Neurology
Georgetown University School of Medicine, Washington, DC	Postdoctoral Fellow	08/2002	Pharmacology, toxicology in herbs, diet and nutrition supplements
University of Maryland School of Medicine, Baltimore, MD	Fellow	05/2005	Pain and inflammation; Acupuncture mechanism, herbal medicine efficacy and safety evaluation

A. Personal Statement

Arthur Yin Fan (Fan Ying) is an independent researcher and a leading specialist in Acupuncture and Chinese Medicine with about three decades of clinical experience in both Traditional Chinese Medicine (TCM) and Western medicine. He was awarded an MD degree in Chinese Medicine (1986) and a PhD in Chinese Internal Medicine (1998); he also had one additional year’s training in the neurology as well as a four-year residency combining Chinese and Western internal medicine, i.e. integrative medicine. He was the first NIH fellow in Chinese medicine in 2002-2005.

Dr. Fan has been a reviewer for medical research grants and academical papers for several peer-reviewed Journals for more than fifteen years; he has published over eighty academical papers. He was a consultant for the center for Integrative Medicine at the University of Maryland medical school. As a researcher in acupuncture, he investigated its effect and mechanism on reducing pain and inflammation. He also researched herbal medicine, nutrition supplements’ efficacy and safety at University of Maryland and Georgetown University Medical School.

Practicing in the Washington, DC-northern Virginia area since 2002, Dr. Fan employs acupuncture and Chinese herbal medicine as alternative or complementary treatment for patients with various conditions. He is one of very few doctors who has both MD and PhD background (in Chinese medicine, integrative medicine). Dr. Fan holds the National Certification Commission for Acupuncture and Oriental Medicine (NCCAOM) certificate in Oriental Medicine.

From 1998 to 2001, Dr. Fan was one of the major designers and founders of Nanjing Chinese Medicine Center for Stroke, which combined the medical resources of ICU, neurology, acupuncture, Chinese herbal medicine, physical therapy, hyperbaric oxygen chamber, and other therapies to maximize patients’ survival and recovery in a limited time. Currently, this center is listed as one of the key stroke centers in China. This kind of integrative medicine style already has spread to every city of China since then.

1. Talpur NA, Echard BW, Fan AY, Jaffari O, Bagchi D, Preuss HG. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol Cell Biochem. 2002 Aug;237(1-2):129-36. PubMed PMID: 12236580.
2. Zhang RX, Lao L, Wang X, Fan A, Wang L, Ren K, Berman BM. Electroacupuncture attenuates inflammation in a rat model. J Altern Complement Med. 2005 Feb;11(1):135-42. PubMed PMID: 15750372.
3. Fan AY, Lao L, Zhang RX, Zhou AN, Berman BM. Preclinical safety evaluation of the aqueous acetone extract of Chinese herbal formula Modified Huo Luo Xiao Ling Dan. Zhong Xi Yi Jie He Xue Bao. 2010 May;8(5):438-47. PubMed PMID: 20456842; PubMed Central PMCID: PMC3739922.
4. Fan AY. The methodology flaws in Hinman’s acupuncture clinical trial, part I: design and results interpretation. J Integr Med. 2015 Mar;13(2):65-8. PubMed PMID: 25797635.

B. Positions and Honors

Positions and Employment

1986 – 1989	Resident doctor, Nanjing Municipal Hospital of Chinese Medicine, Nanjing
1990 – 1990	Fellow/trainee, Nanjing Brain Hospital, Nanjing University of Medical Science, Nanjing
1990 – 1995	Attending doctor, Neurology Department, Nanjing Municipal Hospital of Chinese Medicine, Nanjing
1998 – 2001	Associate Professor in Research and in Internal Medicine; Associate Chief doctor, Neurology Department, The Third Hospital of Nanjing University of Chinese Medicine, Nanjing
2001 – 2002	Visiting researcher, postdoc, Dept. Physiology and Biophysics, Georgetown University Medical Center, Washington, DC
2002 –	Independent researcher in Chinese Medicine, Licensed Acupuncturist, McLean Center for Complementary and Alternative Medicine, PLC, Vienna, VA
2002 – 2005	NIH Fellow in Chinese Medicine, Center for Integrative Medicine, University of Maryland School of Medicine, Baltimore, MD
2004 – 2005	Postdoc, Research assistant, Veteran Affairs Maryland Health Care , Baltimore, MD
2015 –	Chair,Scientific Study & Academic Affair Committee, TCMAAA, Traditional Chinese Medicine American Alumni Association, Largo, FL

Other Experience and Professional Memberships

2008 –	Member, Acupuncture Society of Virginia
2009 – 2010	Board member, Acupuncture Society of Virginia
2015 –	Chair, Scientific Study & Academic Affair Committee, TCMAAA (Traditional Chinese Medicine American Alumni Association, FL, USA).

Honors

1995	Young Scientist Travel Award, International Brain Research Organization
2001	Merit award for Medical Science and Technology Advancement, Jiangsu Provincial Government, China
2011	Member, Editorial Committee, Journal of Integrative Medicine
2013	Editor, Journal of Alternative & Integrative Medicine

C. Contribution to Science

a. Acupuncture clinical trial methodology: design,sample size calculation, statistics, result interpretation

1. Fan AY. The methodology flaws in Hinman’s acupuncture clinical trial, part I: design and results interpretation. J Integr Med. 2015 Mar;13(2):65-8. PubMed PMID: 25797635.
2. Fan AY. The methodology flaws in Hinman’s acupuncture clinical trial, Part II: Zelen design and effectiveness dilutions. J Integr Med. 2015 May;13(3):136-9. PubMed PMID: 26006026.

b. Acupuncture mechanism study in pain and inflammation

1. Zhang RX, Lao L, Wang X, Fan A, Wang L, Ren K, Berman BM. Electroacupuncture attenuates inflammation in a rat model. J Altern Complement Med. 2005 Feb;11(1):135-42. PubMed PMID: 15750372.

c. Herbology efficacy or herb-pharmacology: Huo Luo Xiao Ling Dan; Comparing of the safety between single herb and formula

1. Fan AY, Lao L, Zhang RX, Wang LB, Lee DY, Ma ZZ, Zhang WY, Berman B. Effects of an acetone extract of          Boswellia carterii Birdw. (Burseraceae) gum resin on rats with persistent inflammation. J Altern Complement Med. 2005 Apr;11(2):323-31. PubMed PMID: 15865500.
2. Fan AY, Lao L, Zhang RX, Zhou AN, Wang LB, Moudgil KD, Lee DY, Ma ZZ, Zhang WY, Berman BM. Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats. J Ethnopharmacol. 2005 Oct 3;101(1-3):104-9. PubMed PMID: 15970410
3. Lao L, Fan AY, Zhang RX, Zhou A, Ma ZZ, Lee DY, Ren K, Berman B. Anti-hyperalgesic and anti-inflammatory effects of the modified Chinese herbal formula Huo Luo Xiao Ling Dan (HLXL) in rats. Am J Chin Med. 2006;34(5):833-44. PubMed PMID: 17080548.
4. Zhang RX, Fan AY, Zhou AN, Moudgil KD, Ma ZZ, Lee DY, Fong HH, Berman BM, Lao L. Extract of the Chinese herbal formula Huo Luo Xiao Ling Dan inhibited adjuvant arthritis in rats. J Ethnopharmacol. 2009 Jan 30;121(3):366-71. PubMed PMID: 19100323; PubMed Central PMCID: PMC2818782.

d. Efficacy studies on common used herbs and dietary supplements: Maitake mushroom, Qing Gan Jie Du Dan/ Liver purifier

1. Echard BW, Talpur NA, Fan AY, Bagchi D, Preuss HG. Hepatoprotective ability of a novel botanical formulation on mild liver injury in rats produced by acute acetaminophen and/or alcohol ingestion. Res Commun Mol Pathol Pharmacol. 2001 Jul-Aug;110(1-2):73-85. PubMed PMID: 12090358.
2. Talpur NA, Echard BW, Fan AY, Jaffari O, Bagchi D, Preuss HG. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol Cell Biochem. 2002 Aug;237(1-2):129-36. PubMed PMID: 12236580.
3. Rajaiah R, Lee DY, Ma Z, Fan AY, Lao L, Fong HH, Berman BM, Moudgil KD. Huo-Luo-Xiao-Ling Dan modulates antigen-directed immune response in adjuvant-induced inflammation. J Ethnopharmacol. 2009 May 4;123(1):40-4. PubMed PMID: 19429337; PubMed Central PMCID: PMC2925191.

e. Safety and toxicity evaluation of herbal medicine: Huo Luo Xiao Ling Dan; Literature review; acute toxicity investigation and chronic toxicity evaluation; comparing the single herb and compound formula.

1. Zhang RX, Fan AY, Zhou AN, Moudgil KD, Ma ZZ, Lee DY, Fong HH, Berman BM, Lao L. Extract of the Chinese herbal formula Huo Luo Xiao Ling Dan inhibited adjuvant arthritis in rats. J Ethnopharmacol. 2009 Jan 30;121(3):366-71. PubMed PMID: 19100323; PubMed Central PMCID: PMC2818782.
2. Fan AY, Lao L, Zhang RX, Zhou AN, Berman BM. Preclinical safety evaluation of the aqueous acetone extract of Chinese herbal formula Modified Huo Luo Xiao Ling Dan. Zhong Xi Yi Jie He Xue Bao. 2010 May;8(5):438-47. PubMed PMID: 20456842; PubMed Central PMCID: PMC3739922.

D. Research Support

Completed Research Support

2003/07/31-2004/07/31

Under P50-00084, which was a Feasibility Study

Fan, Arthur Yin (PI)

A Pilot Study on Yang-Deficiency Syndrome And Pain Sensitivity in Rats

Yang-Deficiency (YD, also called Deficiency-cold Syndrome/Pattern, or Yang-Xu Zheng) is a common diagnosis made by traditional Chinese medicine (TCM) in rheumatoid arthritis (RA), osteoarthritis (OA) and other chronic pain or/and chronic inflammatory diseases (CP/CID). YD is marked by chronic cold, frailty or weakness, lethargy, and decreased sexual and reproductive ability or poor body development. TCM Yang-enhancing remedies have demonstrably and effectively corrected these chronic conditions, and the application of such remedies could improve the rehabilitation process of some chronic diseases characterized by YD. In China, YD animal models have been successfully developed by injecting large doses of steroid hormones or by removing the adrenal gland or thyroid gland in rats, mice and rabbits. However, up to now, there has been no study on pain in the YD model or the RA-YD animal model. Our study will consist of two sets of experiments. In part one we will develop YD in Sprague Dawley (SD) rats by injecting them with hydrocortisone acetate daily for one week. We will test their major physiological parameters (body temperature, heart rate, blood pressure); administer endurance tests (anti-fatigue test: 25 ºC room temperature swimming test, anti-cold test under fatigue conditions: 0ºC ice-water swimming test); and measure the functions of three endocrinological axes (cortisone; triiodothyronine [T3], thyroxine [T4]; estradiol [E2], testosterone [T]) using radioimmunoassay (RIA) plasma levels. In part two, we will test the pain sensitivity using behavioral studies (paw withdrawal latency, or PWL) in YD rats compared to normal rats. The data obtained from this study will be used for a future pain and inflammation study, for an herbal remedy study on RA and its Syndromes, and for creating a RA-YD disease-Syndrome integrated animal model.

Role: PI

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My elementary school classmates (1976 Graduated) met in 1980s and 2012, Arthur Fan

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Who is Arthur Yin Fan？

Sometime, patients asked me–

(1) Are you a medical doctor?

(2) What is the difference between other acupuncturist and you?

(3) What is your background？

And, so on………

My reply is:

Arthur Yin Fan is–

* Currently, A licensed acupuncturist (LAc) in Virginia and Washington DC (since 2002); also a Chinese medicine doctor who practices herbology, Tuina, teaches Tai Chi, etc.

* A physician, or  medical doctor, in Chinese medicine and Conventional medicine (in China, from 1986 to 2001), chosen by Chinese goverment as a High-level physician in Chinese Medicine(1999-2000);

* A PhD in Chinese Internal Medicine, and have special trainings in neurology and psychology(in China);

* A researcher / scientist in acupuncture and Chinese herbology studies(safety and effecacy), was a postdoctoral fellow under NIH projects;

* An academic reviewer for CAM research journals, such as JACM; and book publishers;

* An academic consultant for Center for Integrative Medicine, University of Maryland (since 2006);

* A board member in Virginia state acupuncture society(2008-2010);

* The founder and president of Virginia Institute of Traditional Chinese Medicine, VITCM.

He studied Chinese medicine first, then was trained in conventional medicine, he is the person knowing how to bridge Chinese medicine with conventional medicine.

Read more at www.ChineseMedicineDoctor.US; if you consider to see Dr.Arthur Fan, you can click on the link to see the fee schedule and book an appointment online: BOOK NOW.

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Dr.Arthur Fan’s post-doctoral training and clinical experience

After graduated from Nanjing University of Chinese Medicine(Nanjing, China, 1986), Dr.Fan worked 16 years in Nanjing Municipal Hospital of Chinese medicine (i.e. The Third Hospital of Nanjing University of Chinese Medicine, which has 420 beds in Inpatient department, many specialties in Out patient department-half million patient visits per year).

He had 6 years as a  resident doctor (in China, the hospital treats the Resident doctor as employee), 5 years attending doctor, 4 years vice-director doctor. During resident to attending period, he had one year training in another hospital in neurology. During attending to vice-director doctor period, he finished his PhD program in Chinese Internal Medicine and apprenticed under Dr.Zhou Zhongying, a famous Chinese medicine doctor in China.

He had both Chinese medicine and conventional medicine licenses in China(at that time, the original Chinese term is called CHU FANG QUAN, “the prescription right” , which was approved by government HealthCare committee). When he was in China, his former specialty was in Internal Medicine, Neurology.  Because the characteristics of Chinese Medicine (holistic), Dr.Fan also treated many patients who has GYN(such as infertility), ENT issues, when they also have internal problems.

After came in United States(2001), he worked as a postdoctoral fellow in Georgetown University and University of Maryland, focused on Chinese herbology/dietary supplements and acupuncture research; before his coming, Dr.Fan had some reseach work in China too, which helped him understand conventional(“scientific”) methodology and has increased his clinical integrative ability in understanding and treating patients-if the patient has extensive examinations and conventional treatments.

Read more in www.ChineseMedicineDoctor.us

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Dr.Arthur Fan’s medical education

Q:  What is his training background?
Chinese Medicine for 8 years. Studying both TCM and Western medicine, he earned M.D.(5 years’ program, included in one year internship in a university Hospital) and Ph.D. degrees(3 years’ program) in TCM. He took an additional year of training in Western neurology, and completed a six-year residency integrating Western medicine and TCM. 

After his school and hospital training, he also had extensive apprenticeship training under Dr.Zhou Zhongying, one of five top TCM doctors in China(TCM internal medicine), Dr.Xia guicheng, a famous TCM gyn doctor in the world, etc.

Q: What is special about Nanjing University of (Traditional) Chinese Medicine? 
A: Dr.Arthur Yin Fan’s medical school is called Nanjing University of (Traditional) Chinese Medicine is one of five flagship TCM schools in China (as well as in the world). It is the World Health Organization’s Acupuncture training center and traditional medicine collaborating center. 

Q: Comparing to the same specialty’s education, what is the merit educated in Chinese school?

A: Currently in United States, the schools in Oriental medicine offer acupuncture program(master degree,  which is basically 1,200 to 1,700 hours during 3 years, and Oriental/Chinese medicine (master degree) maybe 2,500 to 3,000 hours in 4 years. Some schools also offer additional program for doctoral degree, such as DAOM, etc. (some schools have a special program offering internship in a China’s hospital).  Such students, if pass NCCAOM exams, they could apply acupuncture license to practice acupuncture and Oriental/Chinese medicine, currently although NCCAOM issues the certificate in Oriental Medicine, there is no Oriental doctor license in most of states.

However, for those who already got MD, DC, DO degree, maybe only spend 200 to 300 hours in acupuncture, then could practice acupuncture (medical acupuncturists).  Such condition actually is not good for patients, because acupuncture and Oriental/Chinese medicine totally is another set of medicine; but the law makers in medicine are mostly graduated from the conventional medical schools. And, most researches, such as  from NIH, in acupuncture have been conducted under conventional medicine methology, which may give patients a incorrect cognition.

The education in China for Chinese medicine is 5-6 years’ program, about 4,400 hours and one whole year in hospital as an intern. So, for the education alone, such program may be better than that in United States.

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